USMLE Step 1 Question of the day #78

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Questions:

Cardiology
1. What is the O2 saturation of blood in the umbilical vein of the fetus?

Endocrine
2. How do cholesterol levels change in Hypothyroidism?

Gastrointestinal
3._______ is an anti-HCV agent that is a potent inhibitor of CYP3A4 and P-Glycoprotein.

Biochemistry
4. How do pyruvate levels change in Pyruvate dehydrogenase deficiency?

Renal
5. Which glomerular blood vessel is dilated by Prostaglandins?

Answers:

1. What is the O2 saturation of blood in the umbilical vein of the fetus?
A: 80%; it holds oxygenated blood coming in from the mother
umbilical vein

2. How do cholesterol levels change in Hypothyroidism?
A: Hypercholesterolemia
Due to decreased LDL receptor expression.

3. _______ is an anti-HCV agent that is a potent inhibitor of CYP3A4 and P-Glycoprotein.
A: Telaprevir

4. How do pyruvate levels change in Pyruvate dehydrogenase deficiency?
A: Increased
The build up of Pyruvate gets shunted to Lactate (via LDH) and Alanine (via ALT).

5. Which glomerular blood vessel is dilated by Prostaglandins?
A: Afferent arterioles
Hence, NSAIDs will inhibit afferent arteriole dilation.
Prostaglandins

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