USMLE Step 1 Question of the day #76

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Questions:

Pharmacology
1. _______ is an order of drug elimination that involves a rate of elimination that is directly proportional to the drug concentration.

Hematology/oncology
2. How do Homocysteine levels change in Megaloblastic Anaemia caused by Folate or Vitamin B12 deficiency?

Musculoskeletal, Skin, Connective Tissue
3. What type of anti-inflammatory is Diclofenac?

Neurology
4. Huntington’s Disease is characterized by atrophy of the cortex and the _______ of the basal ganglia, leading to expansion of the ventricles on imaging.

Microbiology
5. How is Babesiosis (Babesia spp.) transmitted?

Answers:

1. _______ is an order of drug elimination that involves a rate of elimination that is directly proportional to the drug concentration.
A: First-order elimination
drug concentration

2. How do Homocysteine levels change in Megaloblastic Anaemia caused by Folate or Vitamin B12 deficiency?
A; Increased
This is due to impaired conversion of Homocysteine to Methionine, a process that requires both Folate and Vitamin B12.

3. What type of anti-inflammatory is Diclofenac?
A: NSAID

4. Huntington’s Disease is characterized by atrophy of the cortex and the _______ of the basal ganglia, leading to expansion of the ventricles on imaging.
A: Caudate nucleus
Huntington's Disease

5. How is Babesiosis (Babesia spp.) transmitted?
A: Ixodes tick
This is the same vector as Borrelia burgdorferi which causes Lyme Disease. Co-infection is common.

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