Nephrogenic Diabetes Insipidus

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Summary1)Fundamentals of Pathology by Hussain Sattar

Nephrogenic Diabetes Insipidus is a disease related to impaired renal response to ADH.

Pathophysiology2)Nephrogenic Diabetes Insipidus (Wikipedia)

Nephrogenic results from lack of Aquaporin channels in the distal collecting duct (decreased surface expression and transcription). It is seen in Lithium toxicity, hypercalcemia, hypokalemia or release of ureteral obstruction.


Diagram of pathology of nephrogenic DI (Essentials of Human Physiology)


Causes3)Fundamentals of Pathology by Hussain Sattar

  • Inherited mutation
  • Drugs

Symptoms 4)Fundamentals of Pathology by Hussain Sattar

  • Polyuria
  • Polydipsia

Diagnosis 5)Fundamentals of Pathology by Hussain Sattar 6)Nephrogenic Diabetes Insipidus (Wikipedia)

  • Blood Chemistry – hypernatremia and high serum osmolality
  • Urinalysis – Low urine osmolality and specific gravity
  • DDAVP Administration – no response

Treatment 7)Nephrogenic Diabetes Insipidus (Wikipedia)

  • Fluid consumption equal to urine produced.
  • Correction of underlying cause.
  • Low-salt and low-protein diet
  • Hydrochlorothiazide and Amiloride

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