Nephrogenic Diabetes Insipidus is a disease related to impaired renal response to ADH.
Pathophysiology2)Nephrogenic Diabetes Insipidus (Wikipedia)
Nephrogenic results from lack of Aquaporin channels in the distal collecting duct (decreased surface expression and transcription). It is seen in Lithium toxicity, hypercalcemia, hypokalemia or release of ureteral obstruction.
- Inherited mutation
Symptoms 4)Fundamentals of Pathology by Hussain Sattar
Diagnosis 5)Fundamentals of Pathology by Hussain Sattar 6)Nephrogenic Diabetes Insipidus (Wikipedia)
- Blood Chemistry – hypernatremia and high serum osmolality
- Urinalysis – Low urine osmolality and specific gravity
- DDAVP Administration – no response
Treatment 7)Nephrogenic Diabetes Insipidus (Wikipedia)
- Fluid consumption equal to urine produced.
- Correction of underlying cause.
- Low-salt and low-protein diet
- Hydrochlorothiazide and Amiloride
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