Diabetic Nephropathy

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Summary1)Diabetic Nephropathy (Wikipedia)

Diabetic Nephropathy is a progressive kidney disease caused by damage to the capillaries in the kidneys’ glomeruli.

Pathophysiology2)Diabetic Nephropathy (Wikipedia)

Diagram depicting Diabetic Nephropathy (Wikipedia)

Diabetes causes a number of changes to the body’s metabolism and blood circulation, which likely combine to produce excess reactive oxygen species (chemically reactive molecules containing oxygen). These changes damage the kidney’s glomeruli (networks of tiny blood vessels), which leads to the hallmark feature of albumin in the urine (called albuminuria).

Causes3)Diabetic Nephropathy (Wikipedia)

  • Poor control of blood glucose
  • High blood pressure
  • Type I DM
  • Cigarette smoking

Symptoms 4)First Aid for the Basic Sciences: Organ Systems by Tao Le

  • Hypertension
  • Edema

Diagnosis 5)First Aid for the Basic Sciences: Organ Systems by Tao Le 6)Diabetic Nephropathy (Wikipedia)

  • Urinalysis – albuminuria
  • Light Microscopy – thickening of CBM and expansion of mesagium

Histology – Thickening of mesangial basement membrane and matrix (Yale School of Medicine)

Treatment 7)First Aid for the Basic Sciences: Organ Systems by Tao Le

  • ACE inhibitors
  • Glucose control with diet, exercise and hypoglycemic agents

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